Comair Flight 5191 began its takeoff roll down the wrong runway early Sunday morning while the controller was busy with paperwork. Also, it was revealed Wednesday, the 47 passengers aboard were unaware that the flight crew had started that Sunday morning by mistakenly getting onto another plane.
The Comair CRJ-100 crashed past the end of Runway 26, killing 49 of 50 people onboard. The co-pilot survived and is in critical condition at a Lexington hospital.
The Federal Aviation Administration on Tuesday acknowledged that having only one controller in the tower violated the agency's policy.

http://www.cnn.com/2006/US/08/30/plane.crash/index.html